https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38300 AntagomiRs are synthetic antagonists of miRNA, which prevent the target mRNA from suppression. Therapeutic approaches that modulate miRNAs have immense potential in the treatment of chronic respiratory disorders. However, the successful delivery of miRNAs/antagomiRs to the lungs remains a major challenge in clinical applications. A range of materials, namely, polymer nanoparticles, lipid nanocapsules and inorganic nanoparticles, has shown promising results for intracellular delivery of miRNA in chronic respiratory disorders. This review discusses the current understanding of miRNA biology, the biological roles of antagomiRs in chronic respiratory disease and the recent advances in the therapeutic utilization of antagomiRs as disease biomarkers. Furthermore our review provides a common platform to debate on the nature of antagomiRs and also addresses the viewpoint on the new generation of delivery systems that target antagomiRs in respiratory diseases.]]> Wed 27 Oct 2021 10:02:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47835 Wed 01 Feb 2023 14:10:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47625 Tue 24 Jan 2023 14:02:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53957 Tue 23 Jan 2024 10:53:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43418 Tue 20 Sep 2022 08:26:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42345 Mon 22 Aug 2022 13:54:38 AEST ]]>